Scientific Publications

This page consists of a library of scientific materials, such as the reports of scientific tests, also called studies that are relevant to your health. This page of our web site is intended to be educational in nature only. Section 5 of the Dietary Supplement Health and Education Act of 1994 (“DSHEA”) permits Ferndale Healthcare, Inc. (Ferndale) to make available to you relevant scientific information as long as Ferndale is not promoting any of its products when doing so. Consistent with that law, Ferndale wants you to understand that it is not in the business of marketing, including advertising, and selling Heliocare® as a product that is intended to prevent, treat, mitigate, or cure any disease or any sign or symptom of a disease. Heliocare® is a dietary supplement that is intended to deliver some specific non-disease health benefits to you.

Please keep in mind that it is important to read the text of the entire study report, although the Discussion, Results and Conclusions part of each study report and other publication will probably be of most interest to most viewers and readers. Finally, please remember the conclusions of the authors of each study may not be shared by all scientists or, possibly, by no other scientists. Often, there are opposing views of the benefit, including the extent of that benefit, of a particular ingredient or product.

The Impact of Oral Polypodium Leucotomos Extract on Ultraviolet B Response: A Human Clinical Study

Scientific Publication

Background: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.

Objective: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).

Methods: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.

Results: Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects…

View full publication – 2017 Journal of the American Academy of Dermatology – Kohli

Polypodium Leucotomos Extract: A Status Report on Clinical Efficacy and Safety

Scientific Publication

Abstract: Various extracts of polypodium leucotomos (PLE) applied topically or taken orally have been shown to have several beneficial antioxidant, photoprotectant, antimutagenic, and immunoregulatory effects. Modern studies have evaluated the efficacy of PLE orally as a photoprotective agent and for use in several photo-aggravated dermatologic disorders such as polymorphous light eruption, other photodermatoses, and melasma. No articles have been published evaluating the safety of PLE. We performed a PUBMED search for any randomized clinical trials related to PLE, or anapsos, a synonym. The primary safety endpoint of the review was any mention of an adverse event, side effect, or toxicity. Overall, 19 human and 6 basic science studies were included spanning over 40 years of research. Oral PLE was administered at daily doses ranging from 120 mg to 1080 mg. No adverse effects were reported in laboratory studies. In humans, side effects (gastro intestinal complaints and pruritus) were mild to moderate and found only in very small numbers of patients overall (16/1016 [2%]). This review concludes PLE is well tolerated at all doses administered and associated with a negligible risk of side effects.

View full publication – 2015 Journal of Drugs in Dermatology – Winkelmann

Polypodium Leucotomos: A Potential New Photoprotective Agent

Scientific Publication

Abstract: As the understanding of the immune system pathways, cytokine balances, and cellular interactions continues to expand, so must the potential applications of therapies that can impact the process of diseases instead of just controlling their symptoms. In the case of Polypodium leucotomos extract, which is derived from a tropical fern of the Polypodiaceae family, the future potential of applications in dermatology and beyond will be better understood as its incorporation into daily routines gives rise to the development of new regimens. Clinicians may position this agent as an option for daily maintenance, accept its use in combinations, or use it as a template for further development of oral supplementation that may evolve into a true immunomodulator…

View full publication – 2015 American Journal of Clinical Dermatology – Bhatia

Sun Protection in a Pill: The Photoprotective Properties of Polypodium Leucotomos Extract

Scientific Publication

Background: Physical blocks (i.e. wearing appropriate clothing), exposure avoidance, and the use of sunscreens are the main methods of photoprotection currently used. However, phytochemical and natural botanical extracts such as polypodium leucotomos, a tropical fern found in Central and South America, demonstrate a strong potential as adjuncts to sunscreen protection.

Method: A review of the literature was performed focusing on the photoprotective properties of PL extracts, including antioxidant, immunoregulatory, anti-inflammatory and antitumorigenic effects in the context of sunburn, photodermatoses, chronic skin damage, photoaging, and skin cancer…

View full publication – 2014 International Journal of Dermatology – El-Haj

Role of Oral Polypodium Leucotomos Extract in Dermatologic Diseases: A Review of the Literature

Scientific Publication

Abstract: Polypodium leucotomos extract (PLE), derived from the tropical fern of Polypodiaceae family, has properties ranging from immunomodulatory and antioxidative to photoprotective. It is these multiple mechanisms of action, in combination with a favorable side effect profile, which makes PLE a promising adjunctive treatment for several dermatologic disorders. Studies are summarized on the use and potential applications of PLE in the treatment or management of photodermatoses, vitiligo, melasma, psoriasis, atopic dermatitis, and more recently, in minimizing infections in high-performance athletes. More data, however, with larger sample sizes are needed to confirm these benefits.

View full publication – 2014 Journal of Drugs in Dermatology – Choudry

Find Heliocare in the vitamins and supplements aisle of your local

Find a Walgreens near you Also available online navigate_next
  • SAVE $3

    Sign up to be informed of future Heliocare promotions! Plus, we’ll send you a coupon for $3 off your next in-store Heliocare purchase!

  • Please enter your first name.
    Please enter your last name.
    There was a problem with subscription. Please try again later.

    Your coupon will be emailed to you and can be used immediately. Or click HERE to download a $3 off coupon to be used in-store.

Thank You!

Your $3 off coupon has been sent to your inbox and should arrive shortly.