The Impact of Oral Polypodium Leucotomos Extract on Ultraviolet B Response: A Human Clinical Study
10/24/17 – Scientific PublicationBackground: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.
Objective: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).
Methods: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.
Results: Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects…
View full publication – 2017 Journal of the American Academy of Dermatology – Kohli
